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PLUMBING FIXTURE LOCATIONS
When designing a floor plan, consider the following in order to avoid redesign:

GROUND FLOORS
Exterior walls
There are several problems caused by locating a fixture on an exterior wall. Structural grade beams, cross-bracing and windows present obstacles which can prevent the installation of service piping unless provisions (sometimes costly) are made. Also, remember that in some geographical areas, piping located within an exterior wall may be subjected to freezing temperatures.
A wall chase, wide enough to extend beyond the interior edge of grade beams and/or cross-bracing, can be provided behind fixtures to accommodate piping, however, this is not a very economical way to utilize square footage. In some cases, waste and vent piping can be installed in walls perpendicular to the exterior wall and adjacent to the fixtures, but this arrangement is limited to only certain types of fixtures.
Always be aware of window locations when placing fixtures. Fixtures may be located below windows, only when the bottom seal is at least 48" above the floor. The wall beneath the window will also require additional reinforcement to compensate for holes that will have to be cut in studs to horizontally route vent and water piping around the window.
If your creativity deserts you and you must locate fixtures on exterior walls, be sure to coordinate with the project Plumbing Designer before proceeding with your design.
Adjacent to columns
The structural foundation below ground floor columns will be larger than the column itself. This can prevent piping from serving the fixture. There seems to be a tendency to corral plumbing fixtures with columns to supposedly save space. However, more space may be required to facilitate a fixture located adjacent to a column than a fixture located where there will be no structure interference.

UPPER FLOORS

Columns, Column Grids, Exterior Walls, Windows
Upper floors provide the same problems for plumbing fixtures as the ground floor with the added bonus of beams and joists. Nine times out of ten, beams will be located on column grid lines.
As you are laying out walls and placing plumbing fixtures, visualize the structural members that will be beneath the floor slab and remember that drain piping serving the fixtures will be penetrating the slab from below.

Sensitive Areas on Lower Floor
Electrical Codes, Health Department Regulations and Hospital Licensing Requirements do not allow Plumbing piping to be located above certain areas, (Electrical Rooms, Food Preparation, Serving, Dining or Storage, Operating Rooms, Nurseries, I.C.U., and other Critical Care Areas) unless special precautions are provided. These Special Precautions usually require the installation of drain pans below all drainage piping above these areas. Obviously, providing drain pans can be costly and will utilize a significant amount of ceiling space. Be aware of the space immediately below the floor you are designing and avoid locating fixtures or equipment served by plumbing above sensitive areas.

Ceiling Space Limitations on Lower Floor
Consider space availability within the ceiling directly below fixtures and equipment. Vaulted ceilings in a lobby, high ceilings in Operating Rooms, etc., can prevent the installation of piping.

SUMMARY

Always be aware of the space demands required by plumbing fixtures. Do not use the structural grid as a homing device for laying out fixtures and restrooms. Think three-dimensionally and visualize spaces above and below the areas you are developing. If you prepare a floor plan without these considerations, something will have to change: The Structural Engineer will have to redesign the structure; or You will have to provide uneconomical, large, wall spaces; or You will have to relocate fixtures and redesign your floor plan. Much of the time spent on your preliminary layout will have been wasted. By realizing the various components of a building while you are in conceptual design, can insure your control of the finished product and save time for everyone.